arXiv:2603.26974v1 Announce Type: new
Abstract: While experiments and computer simulations to study biological phenomena are usually performed in diluted in vitro conditions, such phenomena happen inside the cellular cytoplasm, an environment densely packed with diverse macromolecules. Here, we revise recent computational methods to investigate crowded and cellular environments. Protein crowders, inert crowders and small molecules were used to mimic crowding. Simulations were performed for models of the cytoplasm. New methods were developed to simulate crowded systems. Apart from the challenges, modeling and simulations to investigate biological phenomena inside cells is a growing field, and has a lot of potential to improve our understanding of how such phenomena happen in vivo.
Identifying needs in adult rehabilitation to support the clinical implementation of robotics and allied technologies: an Italian national survey
IntroductionRobotics and technological interventions are increasingly being explored as solutions to improve rehabilitation outcomes but their implementation in clinical practice remains very limited. Understanding patient