ObjectivesMental health services are facing unprecedented demand, placing significant pressure on clinicians to conduct timely and effective patient assessments. Rising staff turnover and burnout threatens service quality across many countries. This study examined whether providing clinical information, collected via an artificial intelligence (AI)—enabled decision support tool for mental health assessments in the UK’s National Health […]
Effectiveness of digital and mobile-based interventions on sleep quality among nurses: a systematic review and meta-analysis
BackgroundNurses frequently endure diminished sleep quality, sleeplessness, and psychological distress due to high-intensity shifts and persistent work pressure. Digital health interventions are increasingly utilised to enhance sleep behaviour; however, systematic information about their real benefits on the nursing population remains insufficient.ObjectiveTo assess the efficacy of digital and mobile interventions on sleep and associated psychological consequences […]
Behavior change beyond intervention: an activity-theoretical perspective on human-centered design of personal health technology
IntroductionModern personal technologies, such as smartphone apps with artificial intelligence (AI) capabilities, have a significant potential for helping people make necessary changes in their behavior (e.g., adopt healthier lifestyles). Current research highlights that realizing this potential through the design and use of personal technologies calls for a critical reappraisal of the role of healthcare interventions […]
A data-centric perspective on designing AI foundation models for healthcare
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Disclosure in the era of generative artificial intelligence
Generative artificial intelligence (AI) has rapidly become embedded in academic writing, assisting with tasks ranging from language editing to drafting text and producing evidence. Despite the wide range of AI use, the expectations for disclosure remain inconsistent. Several journals use binary disclosure statements that fail to distinguish minor language assistance from uses that have a […]
Sanofi’s immunology reckoning; Lilly acquires in vivo CAR-T biotech; RevMed’s ‘Herceptin moment’; and more
Welcome back to another edition of Endpoints Weekly! We’re doing a little bit of celebrating here at Endpoints, as we took home three Neal Awards, which recognize excellence in B2B journalism. The …
Longitudinal assessment of chorea in Huntington’s disease using digital passive monitoring
npj Digital Medicine, Published online: 25 April 2026; doi:10.1038/s41746-026-02661-y Longitudinal assessment of chorea in Huntington’s disease using digital passive monitoring
PIEZOs regulate oligodendrocyte sheath formation, expansion, and myelination potential
Myelination requires precise integration of physical cues by oligodendrocyte lineage cells (OLCs), but the molecular sensors that detect these cues remain incompletely understood. Here, we demonstrate that oligodendrocyte progenitor cells (OPCs) are sensitive to sub-micron changes in membrane displacement. Based on channel properties, RNA expression, and protein abundance, we find that the mechanosensitive ion channel […]
Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex
Neural activity inevitably produces waste, which promotes neurodegeneration with topographic features. The glymphatic system is important for waste clearance. However, the spatial characteristics of glymphatic clearance across cortex and whether it interplays with neural activity in contribution to amyloidosis in human remain unexplored. Here, by intrathecal administration of gadolinium-based contrast agents, glymphatic influx and clearance […]
Coordinated Temporal Dynamics of Glucocorticoid Receptor Binding and Chromatin Landscape Drive Transcriptional Regulation
Glucocorticoid receptor (GR) signaling elicits diverse transcriptional responses through dynamic and context-dependent interactions with chromatin. Here, we define a temporally resolved and mechanistically integrated framework for GR-mediated gene regulation. Time-resolved analyses identify three conserved classes of GR chromatin binding (sustained, transient, and late), distinguished by differences in motif strength, chromatin accessibility, and cofactors engagement. Early […]
PIEZOs regulate oligodendrocyte sheath formation, expansion, and myelination potential
Myelination requires precise integration of physical cues by oligodendrocyte lineage cells (OLCs), but the molecular sensors that detect these cues remain incompletely understood. Here, we demonstrate that oligodendrocyte progenitor cells (OPCs) are sensitive to sub-micron changes in membrane displacement. Based on channel properties, RNA expression, and protein abundance, we find that the mechanosensitive ion channel […]
Coordinated Temporal Dynamics of Glucocorticoid Receptor Binding and Chromatin Landscape Drive Transcriptional Regulation
Glucocorticoid receptor (GR) signaling elicits diverse transcriptional responses through dynamic and context-dependent interactions with chromatin. Here, we define a temporally resolved and mechanistically integrated framework for GR-mediated gene regulation. Time-resolved analyses identify three conserved classes of GR chromatin binding (sustained, transient, and late), distinguished by differences in motif strength, chromatin accessibility, and cofactors engagement. Early […]