arXiv:2604.12301v1 Announce Type: cross
Abstract: We present a systematic measurement study of seven tactics for reducing cloud LLM token usage when a small local model can act as a triage layer in front of a frontier cloud model. The tactics are: (1) local routing, (2) prompt compression, (3) semantic caching, (4) local drafting with cloud review, (5) minimal-diff edits, (6) structured intent extraction, and (7) batching with vendor prompt caching. We implement all seven in an open-source shim that speaks both MCP and the OpenAI-compatible HTTP surface, supporting any local model via Ollama and any cloud model via an OpenAI-compatible endpoint. We evaluate each tactic individually, in pairs, and in a greedy-additive subset across four coding-agent workload classes (edit-heavy, explanation-heavy, general chat, RAG-heavy). We measure tokens saved, dollar cost, latency, and routing accuracy. Our headline finding is that T1 (local routing) combined with T2 (prompt compression) achieves 45-79% cloud token savings on edit-heavy and explanation-heavy workloads, while on RAG-heavy workloads the full tactic set including T4 (draft-review) achieves 51% savings. We observe that the optimal tactic subset is workload-dependent, which we believe is the most actionable finding for practitioners deploying coding agents today.
Dissecting polycomb complexes for enhanced fetal hemoglobin production
Polycomb repressive complexes PRC1 and PRC2 regulate diverse developmental processes, including the fetal-to-adult switch in hemoglobin production, a process whose reversal is a goal for