arXiv:2602.19555v2 Announce Type: replace-cross
Abstract: Agentic systems based on large language models (LLMs) operate not merely as text generators but as autonomous entities that dynamically retrieve information and invoke tools. This execution model shifts the attack surface from traditional build-time artifacts to inference-time dependencies, exposing agents to manipulation through untrusted data and probabilistic capability resolution. While prior work has examined model-level vulnerabilities, security risks arising from the complex, cyclic runtime behavior of agents remain fragmented.
This paper systematizes existing research into a unified runtime framework. We categorize threats into data supply chain attacks (distinguishing between transient context injection and persistent memory poisoning) and tool supply chain attacks (spanning discovery, implementation, and invocation phases). Crucially, we identify the emergence of the Viral Agent Loop, where agents effectively become vectors for self-propagating generative worms that require no code vulnerabilities to spread. We argue for a transition to a Zero-Trust Runtime Architecture, where context is treated as untrusted control flow, and tool execution is bounded by cryptographic provenance rather than semantic likelihood.
Coordinated Temporal Dynamics of Glucocorticoid Receptor Binding and Chromatin Landscape Drive Transcriptional Regulation
Glucocorticoid receptor (GR) signaling elicits diverse transcriptional responses through dynamic and context-dependent interactions with chromatin. Here, we define a temporally resolved and mechanistically integrated framework

