Digital mental health applications enable high-frequency behavioral monitoring and scalable interventions. Journaling provides a therapeutically grounded and intrinsically engaging activity for many users. AI-based text analysis enables privacy-preserving phenotyping of clinically relevant patterns in naturalistic writing, including emotional distress and behavioral risk (e.g., indicators of intent, planning, or preparatory actions for harm to self or […]
Cooperative molecular mimicry drives prolonged autoinflammation in multisystem inflammatory syndrome in children
Multisystem inflammatory syndrome in children (MIS-C) is a pediatric hyperinflammatory disease manifesting 4-6 weeks after SARS-CoV-2 infection. While the immunological hallmarks of MIS-C have been defined, few details regarding the underlying disease pathology have been resolved. To address this, we used a multiomics approach to profile the plasma and peripheral immune cells of 13 acute […]
The Impact of Education Level on the Risk of Heart Failure, Acute Myocardial Infarction, and Stroke in Patients with Atrial Fibrillation – a Swedish Nationwide Cohort Study
Background: Socioeconomic factors impact cardiovascular health. We investigated the association between patient education level and incident heart failure (HF), acute myocardial infarction (AMI), and stroke following a first hospitalization with atrial fibrillation (AF). Methods: In this nationwide retrospective cohort study using linked Swedish national registers, we included all patients receiving a diagnosis of AF while […]
Young Adults’ Interactions With Food and Nutrition Content on Social Media and Implications for Intervention Design: Semistructured Interview Study
Background: Young adults increasingly rely on social media for nutrition information. However, little is known about (1) which types of eating-related content they actively engage with and why, and (2) how they interpret, evaluate, and incorporate this content into their everyday food choices and health behaviors. Objective: This qualitative study explored how UK young adults […]
Telehealth Delivery of the Homeostasis–Enrichment–Plasticity Approach for Premature Infants With Developmental Risks: Exploratory Feasibility Study
Background: Preterm delivery is an increasing worldwide health concern linked to increased neurodevelopmental risks. Early intervention is crucial for harnessing neuroplasticity to enhance developmental and functional performance outcomes; however, access to early intervention is frequently hindered by logistical, financial, and labor constraints. The Homeostasis–Enrichment–Plasticity (HEP) Approach is a family-centered early intervention model based on enriched […]
Feasibility and Acceptability of AI-Powered Tools for Early Autism Screening in Egypt: Semistructured Focus Group Study
Background: Autism spectrum disorder (ASD) is often underdiagnosed in low- and middle-income countries due to limited specialist access, sociocultural stigma, and fragmented screening systems. Artificial intelligence (AI)–powered screening tools may improve early detection by enabling low-cost, accessible assessments. However, adoption depends on stakeholder trust, ethical safeguards, and alignment with local health system capacities. Objective: This […]
Preferences for Personalized Text Message Appointment Reminders Among Outpatients in a Universal Health System: Cross-Sectional Study
Background: SMS text messaging reminders are widely used to reduce missed outpatient appointments; however, evidence remains limited regarding which types of reminder content patients prefer, particularly within East Asian universal health systems. In Taiwan, minimal financial barriers to care and unrestricted access to secondary and tertiary hospitals contribute to high outpatient visit volumes and persistent […]
Electrocardiogram-Based Mental Stress Detection Amid Everyday Activities Using Machine Learning: Model Development and Validation Study
Background: Frequent, sustained stress is linked to poor health and requires monitoring for early intervention. Electrocardiograms (ECG) are promising biomarkers because they can be recorded noninvasively and continuously using wearable devices. However, tracking stress with ECG is challenging because daily activities elicit responses similar to mental stress (MS), and various mental stimuli that individuals encounter […]
A Gamified Mobile Health Intervention to Promote Physical Activity, Executive Function, and Mental Health in College Students: Randomized Controlled Trial
Background: College students commonly experience suboptimal health conditions, including insufficient physical activity (PA), excessive body weight, and declining physical fitness. Traditional interventions face low adherence, while gamified mobile health (mHealth) programs may improve engagement and outcomes. Objective: This study aimed to evaluate the feasibility and effectiveness of a novel gamified, incentive-based mHealth intervention on primary […]
Initial Insights Into an Institutional Secure Large Language Model for Magnetic Resonance Imaging Examination Requests: Retrospective Study
Background: Incomplete clinical details on magnetic resonance imaging (MRI) examination requests (MERs) can lead to suboptimal protocol selection. An institutional secure large language model (sLLM) with access to manually retrieved salient data from the electronic medical record (EMR) may improve request completeness and protocol accuracy across multiple MRI subspecialties. Objective: The objective of this study […]
Social Media Intervention Based on the Information-Motivation-Behavioral Skills Model Promotes HIV Testing and Reduces High-Risk Behaviors Among Men Who Have Sex With Men in Resource-Limited Settings in China: Randomized Controlled Trial
Background: Social media intervention may enhance HIV prevention among men who have sex with men, but the effect of this intervention in resource-limited settings remains unclear. Objective: This randomized controlled trial evaluated whether a social media intervention grounded in the information-motivation-behavioral skills (IMB) model could be beneficial for HIV prevention among men who have sex […]
Changes in Workplace Productivity and Estimated Cost Savings During Internet-Based Cognitive Behavioral Therapy in the Irish National Health Service: Naturalistic, Repeated-Measures, Retrospective Survey Study
Background: Depression and anxiety can significantly impact workplace productivity, for instance, by increasing absenteeism and presenteeism. This loss of productivity leads to diminished workplace economic outcomes. Internet-based cognitive behavioral therapy (iCBT) has emerged as a cost-effective intervention within workplace settings that improves workplace productivity loss due to depression and anxiety, but more generalizable evidence beyond […]