Voltage-gated potassium channels (Kv) are a large family of potassium channels composed of 40 members across 12 subtypes. The KCNH genes encode 3 subfamilies of voltage-gated potassium channels: Kv10 (EAG, ether a go go), Kv11 (ERG, EAG-related gene), and Kv12 (ELK, EAG-like K). Kv channels play prominent roles in the neuronal and cardiovascular systems. Mutations […]
Dissociating volatility and stochasticity reveals transdiagnostic computational signatures of psychopathology
Adaptive learning requires distinguishing volatility, changes in the latent state of the environment, from moment-to-moment stochasticity of observations. The two demand opposite adjustments to the learning rate: volatility calls for faster updating, stochasticity for slower. Disentangling them is computationally difficult because both inflate experienced variance, leaving the inference prone to systematic individual differences with potential […]
Understanding the emergence of the influenza A/H3N2 K subclade in its historical and evolutionary context
The emergence in 2025/26 of the influenza A/H3N2 K substrain (H3N2/K) was the cause of significant public health concern. This genetically divergent virus was assessed to have a strongly decreased reactivity to contemporary vaccine strains. Respectively prolonged and early influenza seasons in the Southern and Northern Hemispheres contributed to concerns about vaccine efficacy. Here we […]
Drosophila-virus genotype interactions dominate transmission, virulence and load, eroding additive fitness variance
Host-parasite coevolution is expected to generate strong selection for susceptibility and infectivity that has the potential to erode genetic variation. Despite this, natural populations often retain extensive genetic variation in these traits. Negative frequency-dependent selection could explain the maintenance of variation since it results in genotype-by-genotype interactions on fitness that, unlike additive genetic variance among […]
Insertion sequence elements associated with Staphylococcus epidermidis evolution in persistent orthopaedic device-related infections
Background Staphylococcus epidermidis is a major cause of orthopaedic device-related infections (ODRIs), which are often challenging to treat due to their extensive antimicrobial resistance (AMR) and biofilm formation. It has been hypothesised that S. epidermidis may rapidly adapt to the medical device niche, enhancing persistence, but direct evidence of within-host pathoadaptive evolution remains limited. Results […]
Multiomic State-Transitions Reveal Post-Treatment Transcriptome Desynchronization in Acute Myeloid Leukemia
Temporal dynamics of the peripheral blood transcriptome are crucial for understanding leukemia evolution and response to therapy because they can reveal how gene expression programs drive abnormal cell states, disease heterogeneity, and treatment resistance. Using a mathematical model of state-transitions, we studied the temporal dynamics of peripheral blood messenger RNA (mRNA) and microRNA (miRNA) transcriptomes […]
Kif2C safeguards radial glial integrity to prevent cortical malformation
Radial glial cells (RGCs) generate cortical neurons and guide radial neuronal migration, yet how microtubule (MT) regulators coordinate progenitor maintenance, mitotic fidelity, and cortical architecture remains unclear. Here, we identify the MT depolymerase Kif2C/MCAK as an essential regulator of RGC integrity with relevance to human neurodevelopmental disorders. Kif2C is enriched in developing cortical RGCs and […]
Monitoring insecticide resistance in mosquitoes from Tunisia: implications for vector control strategies
Tunisia is considered a high-risk country for arboviral transmission, and the re-emergence of malaria. Vector control programs predominantly rely on insecticide-based interventions, however knowledge on the insecticide resistance status of local vectors is limited. Here, we determined the mosquito species composition and investigated the resistance status of disease vectors to insecticides, collected from two distinct […]
IRTKS promotes Tir membrane insertion for intimate bacterial attachment and subsequent pedestal formation
Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen that causes bloody diarrhea and hemolytic uremic syndrome by disrupting the intestinal brush border. During infection, EHEC injects the transmembrane virulence factor Tir into enterocytes; upon insertion into the apical membrane, Tir mediates bacterial attachment and drives formation of actin-rich pedestals needed for colonization. How Tir is […]
TSC2 is a stress granule suppressor
Stress granules (SGs) are dynamic, membrane-less ribonucleoprotein assemblies that form through liquid-liquid phase separation to prioritize stress-survival proteostasis. Through reanalysis of a Drosophila genome-wide RNAi screen, we identified a set of conserved SG suppressor genes and validated the top candidate, Tsc2, in both mouse and human cell lines. We illustrate that the complete loss of […]
TGIF is a golgin-like protein required for Golgi structural maintenance and function in Toxoplasma gondii
The Golgi is an essential organelle that serves as a central hub for endomembrane trafficking. In the protozoan parasite Toxoplasma gondii, a single Golgi stack is essential for parasite survival; however, the molecular determinants governing Golgi structure and function remain poorly understood. Here, we characterize a Golgi-associated protein that is required for Golgi integrity and […]
Investigating the axoneme CCDC40 protein reveals new insights in trypanosome morphogenesis and division
Cilia and flagella contribute to cell morphogenesis in multiple organisms. In the parasite Trypanosoma brucei, the flagellum is attached along the length of the cell body and acts as a guide for cell division, while its motility function is required for the completion of cytokinesis. To tease apart the contributions of flagellum length and motility […]