Single-cell DNA methylation sequencing has remained technically specialized due to challenges of interfacing conversion chemistry with droplet microfluidics. We introduce pre-tagmentation in situ conversion (PreTIC), which enables whole-methylome profiling on a commercial droplet platform using off-the-shelf reagents. With PreTIC, we produce over 13,000 single-cell methylomes from fixed frozen cells in two days and resolve cell-specific epigenetic variation in human peripheral blood mononuclear cells.
SegMix:Shuffle-based Feedback Learning for Semantic Segmentation of Pathology Images
arXiv:2604.15777v1 Announce Type: cross Abstract: Segmentation is a critical task in computational pathology, as it identifies areas affected by disease or abnormal growth and is

